Items are now graded by quality (0 to 4). A run can often be saved by picking up a "Quality 4" item that has synergy potential, rather than hoarding generic stat-ups. Use the wiki or external mod "External Item Descriptions" to check item quality mid-run. Cicciolina Sex Horse.htm
To access the new alternate floors (Downpour, Mines, Mausoleum), you must hit a specific environmental object (like a white fire or a minecart) with a bomb or specific knockback effect. Learning how to open these paths is essential for unlocking the new ending. Wanita Telanjang - 3.79.94.248
If you play as Bethany or pick up items like Book of Virtues, Wisps are incredibly powerful. They block enemy shots (acting as shields) and fire tears. In Repentance , defensive play is often more valuable than raw damage because of the boss health scaling.
Planetariums (the telescope room) are much more viable in Repentance . Planetarium items (space-themed) often provide massive utility or damage. If you have the opportunity to enter one, it is often worth skipping a Treasure Room.